Special Review of 2,4-D: Proposed Decision for Consultation

Re-evaluation Note REV2016-08

Special Review of 2,4-D:

Proposed Decision for

Consultation

(publié aussi en français) 31 March 2016

This document is published by the Health Canada Pest Management Regulatory Agency. For further

information, please contact:

Publications Internet: [email protected]c.ca

Pest Management Regulatory Agency healthcanada.gc.ca/pmra

Health Canada Facsimile: 613-736-3758

2720 Riverside Drive Information Service:

A.L. 6607 D 1-800-267-6315 or 613-736-3799

Ottawa, Ontario K1A 0K9 [email protected]

ISSN: 1925-0630 (print)

1925-0649 (online)

Catalogue number: H113-5/2016-8E (print version)

H113-5/2016-8E-PDF (PDF version)

means, electronic, mechanical, photocopying, recording or otherwise, or stored in a retrieval system, without prior written

permission of the Minister of Public Works and Government Services Canada, Ottawa, Ontario K1A 0S5.

Re-evaluation Note - REV2016-08

Table of Contents

1.0 Introduction ......................................................................................................................... 1

2.0 Uses of 2,4-D in Canada ..................................................................................................... 1

3.0 Aspect of the Pest Control Product that Prompted the Special Review .............................. 2

4.0 PMRA Evaluation of the Aspect of the Pest Control Product that Prompted the Special

Review ................................................................................................................................ 2

4.1. Aspect of concern related to human health ...................................................................... 2

4.2 Aspects of concern related to the environment ................................................................ 3

5.0 Proposed Special Review Decision for 2,4-D ..................................................................... 5

6.0 Next Steps ........................................................................................................................... 5

Appendix I Registered Products Containing 2,4-D as of March 2, 2016 .................................... 7

Table 1 Pest control products containing 2,4-D present as acid ............................................ 7

Table 2 Pest control products containing 2,4-D as amine salt ............................................... 8

Table 3 Pest control products containing 2,4-D present as choline salt .............................. 12

Table 4 Pest control products containing 2,4-D present as ester ......................................... 12

References ................................................................................................................................. 17

Re-evaluation Note - REV2016-08

Page 1

1.0 Introduction

Pursuant to subsection 17(2) of the Pest Control Products Act, the Pest Management Regulatory

Agency (PMRA) has initiated a special review of pest control products containing (2,4-

dichlorophenoxy)acetic acid, commonly known as 2,4-D based on the decision taken by Norway

in 2000 (Rotterdam Convention, 2001) to prohibit the use of this active ingredient due to human

health and environmental concerns. The initiation of the special review for 2,4-D was announced

in December 2013 (Canada, 2013a).

As required by subsection 18(4) of the Pest Control Products Act, the PMRA has evaluated the

aspects(s) of concern related to the pest control products containing 2,4-D that prompted the

special review. The aspects of concern related to the environment were identified as:

 High mobility and the potential for runoff of 2,4-D to aquatic habitats from treated areas

 The potential risk to aquatic plants following runoff.

No concerns for potential risk to aquatic organisms, other than aquatic plants, or for leaching of

2,4-D to groundwater were identified based on information provided by Norway.

In addition, with respect to effects on human health, Norway (Rotterdam Convention, 2001)

concluded that “2.4-D is moderate acute toxic and irritating to eyes, but these characteristics is

comparable to the alternative preparations or active substances. In addition there are some

studies indicating a risk of cancer in soft tissue and lymph, but the evidence isn't strong enough

to label the product for risk of cancer”. Further, the Prior Informed Consent (PIC) Circular XIII

(Rotterdam Convention, 2001) indicated that the expected effect of the final regulatory action in

relation to human health was “reduced risk of cancer in people normally using pesticides with

the agricultural needs covered by Weedar 64”.

Taking into consideration that no specific concerns related to acute properties of 2,4-D were

identified based on information provided by Norway, this aspect was not considered in this

special review. Also, Norway made no conclusion as to the carcinogenic potential of 2,4-D, and

indicated that the “evidence isn’t strong enough to label the product for risk of cancer”

(Rotterdam Convention, 2001). However, given that the PIC Circular XIII also indicated a

reduced risk of cancer in people as an expected effect of the final regulatory action relevant to

human health, the potential carcinogenicity of 2,4-D is considered as part of this special review.

2.0 Uses of 2,4-D in Canada

2,4-D, a selective systemic herbicide, is currently registered in Canada for use on turf, forests

and woodlots, terrestrial feed and food crops, and industrial and domestic non-food sites. 2,4-D

is present in currently registered pest control products as free acid, as amine (dimethylamine,

DMA; isopropylamine, IPA; or triisopropanolamine, TIPA) or choline salts, or in ester form (2-

ethylhexyl, EHE; butoxyethyl ester, BEE). All currently registered pest control products

containing the above forms of 2,4-D (Appendix I) are considered in this special review.

The PMRA published the re-evaluation decision and an update for 2,4-D in 2008 and 2013,

respectively (Canada, 2008; Canada, 2013b). As a result of the re-evaluation, the PMRA

determined that products containing 2,4-D do not present unacceptable risks to human health and

Re-evaluation Note - REV2016-08

Page 2

the environment when used according to the revised conditions of use. The revised use

conditions implemented as a result of the re-evaluation included discontinuation of pest control

products containing the diethanolamine form of 2,4-D, removal of aquatic uses, restriction on the

number of applications, and addition of buffer zones to protect the environment.

3.0 Aspect of the Pest Control Product that Prompted the Special Review

The concerns identified in the 2000 Norwegian decision to prohibit all uses of 2,4-D (Rotterdam

Convention, 2001) were considered for this special review, and they were related to:

 Potential carcinogenicity of 2,4-D;

 High mobility and the potential for runoff of 2,4-D to aquatic habitats from treated areas;

 The potential risk to aquatic plants following runoff.

4.0 PMRA Evaluation of the Aspect of the Pest Control Product that

Prompted the Special Review

Following the initiation of the special review of 2,4-D, the PMRA requested information from

provinces and other relevant federal departments and agencies, in accordance with subsection

18(2) of the Pest Control Products Act. In response, water monitoring data for 2,4-D were

received.

In order to evaluate the aspects of concern for 2,4-D, the PMRA has considered currently

available relevant scientific information, which includes information considered for the re-

evaluation of 2,4-D (Canada 2005; Canada 2006; Canada, 2007; Canada, 2008; Canada, 2013b)

and any relevant information obtained since then, such as the information on Canadian incident

reports, surface water monitoring data, and reviews of epidemiological studies on 2,4-D and

other phenoxy herbicides available in the public domain (see Section 4.1).

4.1. Aspect of concern related to human health

Potential carcinogenicity of 2,4-D

The PMRA review of the available toxicological database for 2,4-D determined that based on in

vitro and in vivo studies, all forms of 2,4-D (acid, salt, or ester forms) are not mutagenic or

genotoxic and, that the overall weight of evidence indicates that 2,4-D is not carcinogenic in rats,

mice, and dogs (Canada, 2007).

In addition to the toxicity studies in animals, the PMRA considered expert assessments of the

evidence available from numerous epidemiological studies on 2,4-D and other phenoxy

herbicides. These studies historically focused on an association between human exposure to

chlorophenoxy herbicides (group of chemicals including 2,4-D and 2,4,5-trichlorophenoxyacetic

acid [2,4,5-T]), and the development of two broad classes of cancer, soft-tissue sarcoma and non-

Hodgkin lymphoma (NHL) in humans. Reviews of epidemiological studies available in the

public domain have concluded that while some of the studies suggest a possible association

between 2,4-D exposure and increase in these tumors in humans, other epidemiological studies

fail to support such association (Canada, 2005; Canada, 2006, Canada, 2007; Burns and Swaen,

2012; Pahwa et al. 2012; Ntzani et al. 2013; von Stackelberg, 2013; Schinasi and Leon, 2014).

Re-evaluation Note - REV2016-08

Page 3

Furthermore, it was concluded that the available epidemiological studies provide equivocal or no

evidence for an association between exposure to 2,4-D (and other chlorophenoxy herbicides) and

other human cancers, including prostate, breast, pancreatic, colorectal, and brain cancers

(Canada, 2008, Weichenthal et al., 2010; Burns and Swaen, 2012, von Stackelberg, 2013). None

of the epidemiological studies relating to 2,4-D exposure in humans have been able to exclude

other confounding factors, including other pesticides, contaminants, fertilizers and fuels,

infectious agents, or lifestyle, that may have contributed to the etiology of reported cancer cases.

The PMRA has also considered assessments of 2,4-D exposure and human cancer conducted by

other regulatory bodies (Canada, 2007) including the most recent assessment from the European

Food Safety Authority (European Commission, 2014), which concluded that 2,4-D is unlikely to

be carcinogenic in humans.

In addition, the PMRA considered the recent information from the International Agency for

Research on Cancer (IARC) (Loomis et al., 2015), which classified 2,4-D as possibly

carcinogenic to humans (IARC Monograph not available as of March 2, 2016). While, the IARC

indicated that there is limited evidence in animals (due to concerns with the conduct of the

positive studies) and inadequate evidence in humans for the carcinogenicity of 2,4-D, the

findings that 2,4-D induces oxidative stress and causes immunosuppression were cited as the

basis for the IARC hazard classification (Loomis et al., 2015). The IARC hazard classifications

are not health risk assessments and the levels of human exposure, which determine the actual

risk, are not taken into account in the IARC assessments.

There are no Canadian human incident reports related to the aspect of concern in the PMRA’s

incident report database.

Overall, taking into consideration, the inconsistent epidemiological associations, the recognition

that there are many other factors that may contribute to the etiology of the reported cancer cases,

information from the PMRA’s incident report database, and the fact that the weight of evidence

from animal studies designed to show causality did not support a carcinogenic effect, the PMRA

has concluded that 2,4-D cannot be classified as a human carcinogen.

4.2 Aspects of concern related to the environment

High mobility and the potential for runoff of 2,4-D to aquatic habitats from treated areas

With respect to their behaviour in the environment, 2,4-D derivatives can be grouped into two

main categories, the acid/amine group (acid, DMA, IPA, TIPA) and the ester group (EHE, BEE).

2,4-D acid and the amine forms are very soluble in water, while the ester forms are insoluble in

water (Canada, 2005; Canada, 2007). Various forms of 2,4-D are non-volatile or have low

volatility. The dissociation constant of 2,4-D (pKa 2.8) indicates that 2,4-D will be present in its

ionic form under the pH conditions prevailing in most Canadian soils and water bodies. The

amine and choline forms dissociate to the acid form in the presence of water within a few

minutes.

Hydrolysis is not an important route of transformation for 2,4-D acid and the amine forms, or for

the esters under acidic or neutral pH levels. However, it is an important route of transformation

of the esters to the acid under alkaline pH conditions (half-lives of EHE and BEE are 2 days and

Re-evaluation Note - REV2016-08

Page 4

0.07 day, respectively). Phototransformation is also not an important route of transformation for

2,4-D in the environment (Canada, 2007). Aerobic biotransformation is the major route of

transformation of 2,4-D in soil and water. 2,4-D acid and its derivatives are classified as non-

persistent to slightly persistent in soil and water (half-lives 0.22 -31 days soil; 0.25-29 days in

water). Major biotransformation products of 2,4-D are carbon dioxide (CO

) in soil and, CO

2,4-dichlorophenol (2,4-DCP) and chlorohydroquinone (CHQ) in water. Under anaerobic soil

and aquatic systems, 2,4-D is considered to be persistent.

The organic carbon adsorption coefficient of 2,4-D (K

<150) indicates that 2, 4-D is weakly

absorbed to soil and it is not expected to partition significantly to soil and sediment. On this

basis, 2,4-D is expected to be highly mobile in soils and it is expected to runoff from the treated

areas into aquatic systems following irrigation or rainfall (Canada 2005; Canada, 2007).

The potential risk to aquatic plants following runoff

To assess the potential risk to aquatic plants from runoff, the PMRA considered the surface water

monitoring and modelling information as well as the toxicity to aquatic plants from exposure to

2,4-D.

The PMRA calculated the potential estimated environmental concentrations (EECs) of acid/salt

and esters forms of 2,4-D in surface water using the PRZM/EXAM model or assuming a direct

overspray. In addition, robust surface water monitoring data for 2,4-D from Canada and the

United States were considered.

The PMRA assessed the risk to aquatic plants using the risk quotient (RQ) method which is

expressed as the ratio of the EEC to the most sensitive endpoints for the different derivatives of

2,4-D for aquatic plants. The estimated risk quotient is then compared to the level of concern

(LOC). For exposures to aquatic organisms, the PMRA’s LOC is 1.0.

For turf uses, the calculated RQs range from 0.3 to 2.9 for the acid and amine forms, and 3.0 to

5.8 for the ester forms based on the conservative (direct overspray) EECs ranging from 0.543 to

0.788 mg a.e./L and the NOECs of 2.03 and 0.27 mg a.e./L (Lemna gibba) for the acid amine

forms, respectively, 0.094 mg a.e./L (Skeletonema costatum) for EHE, and 0.20 mg a.e./L

(Lemna gibba) for BEE.

For agriculture/non-crop/forestry uses, the calculated RQs for aquatic plants range from 0.04 to

1.4 for the acid and amine forms, 0.05 to 1.5 for EHE, and from 0.04 to 1.3 for BHE forms based

on the runoff EECs ranging from 0.008 to 0.345 mg a.i./L and the static 14-day EC

(0.5 × EC

values used in the risk assessment) of 0.48 mg a.i./L (Lemna gibba) for the acid and amine

forms, 0.33 mg a.i./L (Lemna gibba) for EHE, and 0.40 mg a.i./L (Lemna gibba) for BHE.

The estimated amine RQs (0.04-1.4) are representative of the risk posed by the choline form

since these two forms are considered to be toxicologically equivalent.

It should be noted that the EECs were generated using conservative assumptions and, therefore,

the potential risk to aquatic plants is considered unlikely. This is further supported by the

available monitoring information. When the available surface water monitoring information was

considered, the risk to aquatic plants was deemed to be unlikely. Based on the highest

Re-evaluation Note - REV2016-08

Page 5

concentration detected in Canada in urban runoff (0.0469 mg/L) and in the most recent (2002-

2014) surface water monitoring (0.011 mg/L), the risk to aquatic plants from 2,4-D is not a

concern.

To minimize the potential runoff from treated areas into aquatic habitats, advisory label

statements are currently included on the products labels advising the users of measures that can

help reduce runoff.

No concerns related to the aspect of concern (mobility and potential risk to aquatic plants

following runoff) were identified in the information received through the Canadian incident

report database.

Consequently, based on the results of the risk assessment and taking into consideration the

current conditions of use for pest control products containing 2,4-D, the PMRA has determined

that the risk to aquatic plants from 2,4-D in runoff is not of concern.

5.0 Proposed Special Review Decision for 2,4-D

Evaluation of available scientific information related to the aspects of concern for human health

and the environment, indicated that the registered products containing 2,4-D are acceptable for

continued registration taking into account the current conditions of use. On this basis, the PMRA

is proposing to confirm the current registration of products containing 2,4-D for sale and use in

Canada pursuant to subsection 21(1) of the Pest Control Product Act.

This proposed special review decision is a consultation document

. The PMRA will accept

written comments on this proposal up to 45 days from the date of publication of this document.

Please forward all comments to Publications (please see contact information on the cover page of

this document).

6.0 Next Steps

Before making a special review decision on 2,4-D, the PMRA will consider any comments

received from the public in response to this consultation document. A science-based approach

will be applied in making a final decision on 2,4-D. The PMRA will then publish a special

review decision document, which will include the decision, the reasons for it, a summary of the

comments received on the proposed decision and the PMRA’s response to these comments.

“Consultation statement” as required by subsection 28(2) of the Pest Control Products Act.

Re-evaluation Note - REV2016-08

Page 6

Appendix I

Re-evaluation Note - REV2016-08

Page 7

Appendix I Registered Products Containing 2,4-D as of March 2, 2016

Table 1 Pest control products containing 2,4-D present as acid

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

16981 T

Dow

Agrosciences

Canada Inc.

2,4-

Dichlorophenoxyacetic

Acid Flake Technical

Herbicide

Solid 97.0%

17007 T

Nufarm

Agriculture Inc.

Growell 2,4-D

Technical Acid

Solid 98.5%

17044 T

Nufarm

Agriculture Inc.

Nufarm 2,4-D

Technical Acid

Solid 98.5%

17134 T

Nufarm

Agriculture Inc.

Nufarm 2,4-D Dry

Powder Acid Herbicide

Solid 97.5%

17291 T PBI/Gordon Corp

2,4-

Dichlorophenoxyacetic

Acid Technical

Solid 98.2%

24562 T

Nufarm

Agriculture Inc.

Nufarm 2,4-D

Technical Acid

Solid 96.0%

24836 T

Dow

Agrosciences

Canada Inc.

2,4-

Dichlorophenoxyacetic

Acid Molten Technical

Herbicide

Solution 74.8%

27437 T Albaugh Inc.

Albaugh 2,4-D

Technical Acid

Herbicide

Solid 97.63%

28491 T

Nufarm

Agriculture Inc.

Nufarm 2,4-D

Technical Acid

Herbicide

Solid 97.0%

25783 M

Dow

Agrosciences

Canada Inc.

Striker Manufacturing

Concentrate

Wettable

Granules

FLM-9.3%

DXA-50.0 %

DPI-25.0%

27991 M PBI/Gordon Corp.

Trimec DMB #2

Herbicide Powder Plus

Dust or

Powder

MEP-10.20%

DXA-45.59%

DIC-4.30%

9342 C

Nufarm

Agriculture Inc.

Nufarm Calmix Pellets

Weed Killer & Soil

Sterilant

Pellets

DXA-5.0%

BBU-3.0%

27634 C

Dow

Agrosciences

Canada Inc.

Grazon Herbicide Solution

PID-65 g/L

DXA-240 g a.e./L

31641 C

Dow

Agrosciences

Canada Inc.

Aspect Herbicide Solution

PID-97.5 g/L

DXA-360 g a.e./L

31642 C

Dow

Agrosciences

Canada Inc.

Grazon XC Herbicide Solution

PID-97.5 g/L

DXA-360 g a.e./L

11852 D

Les Produits De

Controle

Superieur Inc./

Superior Control

Products Inc.

Weedex Dandelion Bar Solid 14.55%

Appendix I

Re-evaluation Note - REV2016-08

Page 8

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

21738 D

Les Produits De

Controle

Superieur Inc./

Superior Control

Products Inc.

Weedex Dandelion

Stick

Solid 6.79%

T - Technical grade; M – Manufacturing concentrate; C – Commercial; D – domestic

a.e. – acid equivalent; DXA - 2,4-D (present as acid); BBU – Bromacil; DPI - Clopyralid; DIC - Dicamba; FLM - Flumetsulam; MEP -

Mecoprop-P; PID – Picloram;

Table 2 Pest control products containing 2,4-D as amine salt

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

16988 M Dow

Agrosciences

Canada Inc.

2,4-D DMA 720

Unsequestered

Weed Killer

Solution 55.7%

17107 M Dow

Agrosciences

Canada Inc.

2,4-D DMA 720

Sequestered Weed

Killer

Solution 55.5%

17138 M Nufarm

Agriculture Inc.

Nufarm 2,4-D

Amine

Unsequestered

Manufacturing

Concentrate

Solution 683 g a.e./L

17401 M Nufarm

Agriculture Inc.

Nufarm 2,4-D DMA

Manufacturing

Concentrate

Solution 720 g a.e./L

18352 M Nufarm

Agriculture Inc.

Growell 2,4-D

Dimethylamine Salt

720 Formulation

Solution 720 g a.e./L

19530 M Dow

Agrosciences

Canada Inc.

2,4-D

Isopropylamine Salt

Solution 39.4%

27165 M Nufarm

Agriculture Inc.

Growell 2,4-D

Dimethylamine Salt

683 Formulation

Solution 683 g a.e./L

27721 M Scotts Canada

Ltd.

Killex 3x

Manufacturing

Concentrate Ii

Solution MEQ-157.5 g a.e./L

DXB-285 g a.e./L

DIC-27 g a.e./L

27808 M Interprovincial

Cooperative

Limited

IPCO 2,4-D/

Mecoprop-P

Formula 3 XP

Solution MEQ-180 g a.e./L

DXB-360 g a.e./L

27867 M Loveland

Products Canada

Inc.

Mecoprop-P + 2,4-D

Manufacturing

Concentrate

Solution MEQ-180 g a.e./L

DXB-360 g a.e./L

5931 C Loveland

Products Canada

Inc.

2,4-D Amine 600

Herbicide

Solution 564 g a.e./L

9007 C Dow

Agrosciences

Canada Inc.

Tordon 101

Herbicide

Solution PID-65 g /L

DXB-240 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 9

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

9528 C Dow

Agrosciences

Canada Inc.

2,4-D Amine 500

Herbicide

Solution 470 g a.e./L

14167 C Dow

Agrosciences

Canada Inc.

Tordon 202c Liquid

Herbicide

Solution PID-12 g/L

DXB-200 g a.e./L

14725 C Nufarm

Agriculture Inc.

Nufarm 2,4-D

Amine 500 Liquid

Herbicide

Solution 470 g a.e./L

14726 C Nufarm

Agriculture Inc.

Nufarm 2,4-D

Amine 600 Liquid

Herbicide

Solution 564 g a.e./L

15730 C Agrium Advanced

Technologies RP

Inc.

Wilson 2,4-D

Amine 500 Liquid

Weed Killer

Solution 470g a.e./L

17511 C Interprovincial

Cooperative

Limited

IPCO 2,4-D Amine

600 Liquid

Herbicide

Solution 560 g a.e./L

19536 C Monsanto Canada

Inc.

Rustler

Summerfallow

Herbicide

Solution GPI-108 g a.e./L

DXB-182 g a.e./L

25898 C Monsanto Canada

Inc.

Mon 77790

Herbicide

Solution GPI-132 g a.e./L

DXB-82 g a.e./L

26163 C Interprovincial

Cooperative

Limited

Weedaway 2,4-D

Amine 600 Liquid

Herbicide

Solution 560 g a.e./L

26649 C Dow

Agrosciences

Canada Inc.

Ram Herbicide Solution PID-65 g a.e./L

DXB-240 g a.e./L

27779 C Interprovincial

Cooperative

Limited

IPCO Premium 2-

Way XP Turf

Herbicide Liquid

Solution MEQ-200g a.e./L

DXB-200g a.e./L

27846 C Interprovincial

Cooperative

Limited

IPCO Premium 3-

Way XP Herbicide

Solution MEQ-100g a.e./L

DXB-190g a.e./L

DIC-18g a.e./L

27848 C Interprovincial

Cooperative

Limited

Weedaway Premium

3-Way XP Turf

Herbicide

Solution MEQ-100g a.e./L

DXB-190g a.e./L

DIC-18g a.e./L

27856 C Basf Canada Inc. Dyvel DSP Liquid

Herbicide

Solution MEQ-80g a.e./L

DXB-295g a.e./L

DIC-110g a.e./L

27884 C Loveland

Products Canada

Inc.

Par III Turf

Herbicide

Solution MEQ-100g a.e./L

DXB-190g a.e./L

DIC-18g a.e./L

27972 C Nufarm

Agriculture Inc.

Nufarm Trillion

Turf Herbicide

Solution MEQ-100g a.e./L

DXB-190g a.e./L

DIC-18g a.e./L

27969 C Agrium Advanced

Technologies RP

Inc.

Wilson Turf Rite

2+2 Double

Strength Herbicide

Solution DXB-200 g a.e./L

MEQ-200 g a.e./L

27970 C Agrium Advanced

Technologies RP

Inc.

Pro Tri-Kil Turf

Herbicide

Solution MEQ-100 g a.e./L

DXB-190 g a.e./L

DIC-18 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 10

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

27972 C Nufarm

Agriculture Inc.

Nufarm Trillion

Turf Herbicide

Solution MEQ-100 g a.e./L

DXB-190 g a.e./L

DIC-18 g a.e./L

27975 C Scotts Canada

Ltd.

Green Cross Killex

500 Liquid Turf

Herbicide

Concentrate

Solution MEQ-75.0g a.e./L

DXB-385.25g a.e./L

DIC-18.75g a.e./L

27976 C Scotts Canada

Ltd.

Green Cross Killex

Liquid Turf

Herbicide

Concentrate

Solution MEQ-100g a.e./L

DXB-190g a.e./L

DIC-18g a.e./L

27987 C Syngenta Canada

Inc.

Target Ds Liquid

Herbicide

Solution MEQ-80g a.e./L

DXB-295g a.e./L

DIC-110g a.e./L

28271 C Dow

Agrosciences

Canada Inc.

2,4-D Amine 600

Herbicide

Solution 564g a.e./L

28295 C Dow

Agrosciences

Canada Inc.

Formula 40F

Herbicide

Solution 470g a.e./L

28296 C Dow

Agrosciences

Canada Inc.

Formula 40C

Herbicide

Solution 470g a.e./L

28552 C Dow

Agrosciences

Canada Inc.

Restore B Herbicide

(A Component Of

Restore Herbicide)

Solution 564g a.e./L

29248 C Interprovincial

Cooperative

Limited

Viterra 2,4-D Amine

600 Liquid

Herbicide

Solution 560g a.e./L

30532 C Intelligro Civitas Weedfree

Brand Concentrate

Emulsifiable

Concentrate

Or Emulsion

MEQ-4.04g a.e./L

DXB-6.33g a.e./L

DIC-0.78g a.e./L

30632 C Dow

Agrosciences

Canada Inc.

Restore II Herbicide Solution DXB-400g a.e./L

AMD-50.0g a.e./L

31332 C Albaugh Inc. Albaugh 2,4-D

Amine 600

Solution 560g a.e./L

27799 D Scotts Canada

Ltd.

Ortho Killex Ready-

To-Use Lawn Weed

Control Herbicide

With Quick Connect

Sprayer

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

27800 D Scotts Canada

Ltd.

Ortho Killex Ready-

To-Use Lawn Weed

Control Herbicide

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

27801 D Scotts Canada

Ltd.

Ortho Killex Lawn

Weed Control

Concentrate

Solution MEQ-52.52g a.e./L

DXB-95g a.e./L

DIC-9g a.e./L

27809 D Scotts Canada

Ltd.

Ortho Killex Ready-

To-Spray Lawn

Weed Control

Solution MEQ-52.52 g a.e./L

DXB-95 g a.e./L

DIC-9 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 11

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

27811 D Scotts Canada

Ltd.

Ortho Killex With

Pull N' Spray

Applicator Ready-

To-Use

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

27914 D Interprovincial

Cooperative

Limited

Co-Op Premium

Spot Weed Killer

XP Herbicide

Solution MEQ-1.00 g a.e./L

DXB-1.90 g a.e./L

DIC-0.18 g a.e./L

27915 D Interprovincial

Cooperative

Limited

Co-Op Premium

Lawn Weed Killer

XP Herbicide

Solution MEQ-50 g a.e./L

DXB-95 g a.e./L

DIC-9 g a.e./L

27974 D Sure-Gro IP Inc. Wilson Lawn

Weedout Ready To

Use

Solution MEQ-3.0 g a.e./L

DXB-3.0 g a.e./L

DIC-0.3 g a.e./L

28000 D Sure-Gro IP Inc. Wilson Lawn

Weedout (2) Ready

To Use

Solution MEQ-3.0 g a.e./L

DXB-3.0 g a.e./L

DIC-0.3 g a.e./L

28078 D Sure-Gro IP Inc. Wilson Lawn

Weedout Attach &

Spray Concentrate

Solution MEQ-25 g a.e./L

DXB-50 g a.e./L

DIC-4.5 g a.e./L

28081 D Sure-Gro IP Inc. Wilson Lawn

Weedout

Concentrate

Solution MEQ-50 g a.e./L

DXB-95 g a.e./L

DIC-9 g a.e./L

28204 D Les Produits De

Controle

Superieur Inc/

Superior Control

Products Inc.

Concentrated

Weedex Weed

Control For Lawns

Solution MEQ-50 g a.e./L

DXB-95.0 g a.e./L

DIC-9 g a.e./L

28209 D Les Produits De

Controle

Superieur Inc/

Superior Control

Products Inc.

Ready To Use

Weedex Weed

Control For Lawns

Solution MEQ-1.0 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

28310 D Scotts Canada

Ltd.

Ortho Killex Ready-

To-Use Herbicide II

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

28311 D Scotts Canada

Ltd.

Ortho Killex With

Pull'n Spray

Applicator Ready-

To-Use Herbicide II

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

28312 D Scotts Canada

Ltd.

Ortho Killex Lawn

Weed Control

Ready-To-Use

Herbicide II

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

28374 D Scotts Canada

Ltd.

Ortho Killex Ready-

To-Use Herbicide

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

28513 D Les Produits De

Controle

Superieur Inc./

Superior Control

Products Inc.

Ready To Use

Weedex With 1

Touch Power

Sprayer

Solution MEQ-1.0 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 12

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

30536 D Intelligro Clear Choice(Tm)

Ready-To-Use

Selective Herbicide

Emulsifiable

Concentrate

MEQ-0.30 g a.e./L

DXB-0.47 g a.e./L

DIC-0.058 g a.e./L

30541 D Scotts Canada

Ltd.

Ortho® Killex®

Ready-To-Use With

Wand Applicator

Solution MEQ-1.05 g a.e./L

DXB-1.9 g a.e./L

DIC-0.18 g a.e./L

31028 D Sure-Gro IP Inc. Smartones Lawn

Weeder

Solution MEQ-1.0 g a.e./L

DXB-1.90 g a.e./L

DIC-0.18 g a.e./L

T - Technical grade =, M – Manufacturing concentrate; C – Commercial; D – domestic

a.e. – acid equivalent; DXB - 2,4-D (present as amine salts: dimethylamine salt, diethanolamine salt, or other amine salts); AMD –

Aminopyralid; DIC – Dicamb); GPI – Glyphosate; MEQ – Mecoprop-p-dimethylammonium; PID – Picloram;

Table 3 Pest control products containing 2,4-D present as choline salt

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

30956 M

Dow Agrosciences

Canada Inc.

GF-2668

Manufacturing

Concentrate

Solution 44.5%

30957 C

Dow Agrosciences

Canada Inc.

GF-2654 TC Herbicide Solution 456 g a.e./L

30958 C

Dow Agrosciences

Canada Inc.

Enlist Duo Herbicide Solution

GPX-204 g a.e./L

DXJ-194 g a.e./L

30959 C

Dow Agrosciences

Canada Inc.

GF-2654 Tsoy

Herbicide

Solution 456 g a.e./L

30960 C

Dow Agrosciences

Canada Inc.

FGf-2726 Tsoy

Herbicide

Solution

GPX-204 g a.e./L

DXJ-194 g a.e./L

M – Manufacturing concentrate; C – Commercial

a.e. – acid equivalent; DXJ – 2,4-D (present as choline salt); GPX – Glyphosate

Table 4 Pest control products containing 2,4-D present as ester

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

16982 T

Dow Agrosciences

Canada Inc.

Dow 2,4-D 2-

Ethylhexyl Ester

Emulsifiable

Concentrate

Or Emulsion

63.9% a.e.

16990 T

Dow Agrosciences

Canada Inc.

2,4-D Butoxy

Ethanol Esters

Liquid 66.4% a.e.

17012 T

Nufarm Agriculture

Inc.

Growell 2,4-D 2-

Ethylhexyl Ester

Technical

Solution 64.0% a.e.

17135 T

Nufarm Agriculture

Inc.

Nufarm 2,4-D 2-

Ethylhexyl Ester

Technical

Liquid 64.3% a.e.

27263 T

Nufarm Agriculture

Inc.

Nufarm 2,4-D 2-

Ethylhexyl Ester

Technical

Emulsifiable

Concentrate

64.0% a.e.

28490 T

Nufarm Agriculture

Inc.

Nufarm 2,4-D 2-

Ethylhexyl Ester

Technical Herbicide

Emulsifiable

Concentrate

63.9%

Appendix I

Re-evaluation Note - REV2016-08

Page 13

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

29964 T Albaugh Inc.

Albaugh 2,4-D 2-Eh

Ester Technical

Liquid 62.12% a.e.

15981 R

Dow Agrosciences

Canada Inc.

Esteron Herbicide

Emulsifiable

Concentrate

564 g a.e./L

27818 C+R

Loveland Products

Canada Inc.

Salvo 2,4-D Ester

700 Herbicide

Emulsifiable

Concentrate

660 g a.e./L

27819 C+R

Interprovincial

Cooperative Limited

IPCO 2,4-Dester 700

Herbicide

Emulsifiable

Concentrate

660 g a.e./L

27820 C+R

Nufarm Agriculture

Inc.

Nufarm 2,4-D Ester

700 Liquid Herbicide

Emulsifiable

Concentrate

660 g a.e./L

29007 C+R

Interprovincial

Cooperative Limited

Weedaway 2,4-D

Ester 700 Herbicide

Emulsifiable

Concentrate

660 g a.e./L

29264 C+R

Dow Agrosciences

Canada Inc.

2,4-D LV-700

Herbicide

Emulsifiable

Concentrate

660 g a.e./L

31698 C+R

Adama Agricultural

Solutions Canada

Ltd.

Adama 2,4-D Ester

700 Liquid Herbicide

Emulsifiable

Concentrate

660 g a.e./L

6330 C

Dow Agrosciences

Canada Inc.

2,4-D Bee-4

Herbicide

Emulsifiable

Concentrate

500 g a.e./L

9560 C

Dow Agrosciences

Canada Inc.

2,4-D LV-600

Herbicide

Emulsifiable

Concentrate

564 g a.e./L

15027 C

Nufarm Agriculture

Inc.

Nufarm Desormone

Liquid Herbicide

Emulsifiable

Concentrate

DXF-330 g a.e./L

DIH-350 g a.e./L

20310 C

Interprovincial

Cooperative Limited

IPCO 2,4-D Ester

700 Low Volatile

Liquid Herbicide

Emulsifiable

Concentrate

660 g a.e./L

22659 C

Bayer Cropscience

Inc.

Thumper

Emulsifiable

Selective Weedkiller

Emulsifiable

Concentrate

DXF-280 g a.e./L

BRY-280 g a.e./L

24833 C

Dow Agrosciences

Canada Inc.

Attain B Herbicide

(A Component of

Attain Herbicide

Tank Mix)

Emulsifiable

Concentrate

564 g a.e./L

27243 C

Dow Agrosciences

Canada Inc.

Frontline 2,4-D B

Emulsifiable

Concentrate

Herbicide (A

Component of

Frontline 2,4-D

Herbicide Tank Mix)

Emulsifiable

Concentrate

564 g a.e./L

27879 C Basf Canada Inc.

Adrenalin SC

Herbicide

Emulsifiable

Concentrate

IMZ-20 g a.e./L

DXF-560 g a.e./L

27966 C

Interprovincial

Cooperative Limited

IPCO Dichlorprop-D

Herbicide

Emulsifiable

Concentrate

DXF-282 g a.e./L

DIH-300 g a.e./L

27967 C

Loveland Products

Canada Inc.

Turboprop

Emulsifiable

Concentrate

DXF-282 g a.e./L

DIH-300 g a.e./L

28123 C

Nufarm Agriculture

Inc.

Approve Herbicide

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

28779 C

Adama Agricultural

Solutions Canada

Ltd.

Thrasher

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

28853 C

Interprovincial

Cooperative Limited

IPCO Leader Liquid

Herbicide

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 14

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

28947 C

Interprovincial

Cooperative Limited

IPCO Leader 450

Liquid Herbicide

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

29513 C

Bayer Cropscience

Inc.

Thumper Total 2

Herbicide (A

Component of

Thumper Total

Herbicide Tank Mix)

Emulsifiable

Concentrate

DXF-280 g a.e./L

BRY-280 g a.e./L

29660 C

Nufarm Agriculture

Inc.

Nufarm Estaprop XT

Liquid Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

29663 C

Nufarm Agriculture

Inc.

Desormone XT

Liquid Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

29664 C

Interprovincial

Cooperative Limited

IPCO Dichlorprop-

DX Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

29750 C

Dow Agrosciences

Canada Inc.

Reclaim B Herbicide

Emulsifiable

Concentrate

564 g a.e./L

29972 C

Dow Agrosciences

Canada Inc.

Attain XC B

Herbicide

Emulsifiable

Concentrate

660 g a.e./L

29979 C Albaugh Inc.

Agri Star 2,4-D Ester

700

Emulsifiable

Concentrate

660 g a.e./L

30005 C

Interprovincial

Cooperative Limited

Weedaway Leader

Herbicide

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

30061 C

Dow Agrosciences

Canada Inc.

Frontline 2,4-D Xc B

Herbicide (A

Component of

Frontline 2,4-D XC

Herbicide)

Emulsifiable

Concentrate

660.0 g a.e./L

30063 C

Dow Agrosciences

Canada Inc.

Reclaim Ii B

Herbicide (A

Component of

Reclaim II Herbicide)

Emulsifiable

Concentrate

660 g a.e./L

30077 C

Dow Agrosciences

Canada Inc.

Octtain XL Herbicide

Emulsifiable

Concentrate

FLR-90 g a.e./L

DXF-360 g a.e./L

30103 C

Interprovincial

Cooperative Limited

Dichlorprop-DX

Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

30111 C

Interprovincial

Cooperative Limited

Weedaway

Dichlorprop-DX

Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

30112 C

Interprovincial

Cooperative Limited

Viterra Dichlorprop-

DX Herbicide

Emulsifiable

Concentrate

DXF-400 g a.e./L

DPZ-210 g a.e./L

30372 C

Adama Agricultural

Solutions Canada

Ltd.

Thrasher II

Emulsifiable

Concentrate

DXF-225 g a.e./L

BRY-225 g a.e./L

30460 C Newagco Inc.

Mpower 2,4-D Ester

700

Emulsifiable

Concentrate

660 g a.e./L

30690 C

Nufarm Agriculture

Inc.

Enforcer D Herbicide

Emulsifiable

Concentrate

FLR-80 g a.e./L

DXF-240 g a.e./L

BRY-190 g a.e./L

31626 C

Dow Agrosciences

Canada Inc.

Scuttle Herbicide

Emulsifiable

Concentrate

FLR-90 g a.e./L

DXF-360 g a.e./L

31673 C Syngenta Canada Inc.

Traxos®Two

Broadleaf

Component

Emulsifiable

Concentrate

FLR-90 g a.e./L

DXF-360 g a.e./L

Appendix I

Re-evaluation Note - REV2016-08

Page 15

Registration

Number

Marketing

Class

Registrant Product Name Formulation Guarantee

32111 C

Nufarm Agriculture

Inc.

Blackhawk herbicide

Emulsifiable

Concentrate

DXF 473 g a.e./L

PFE 6.1 g/L

T – Technical grade; M – Manufacturing concentrate; R – Restricted; C + R – Commercial plus Restricted uses; C – Commercial

a.e. – acid equivalent; DXF – 2,4-D (present as low volatile esters); BRY – Bromoxynil; DIH – Dichlorprop; DPZ - Dichlorprop-P-2-

ethylhexyl; FLR- Fluroxypyr; IMZ – Imazamox; PFE - Pyraflufen‐ethyl

Appendix I

Re-evaluation Note - REV2016-08

Page 16

References

Re-evaluation Note - REV2016-08

Page 17

References

Published Information

PMRA

Number

Reference

1011609 Canada, 2005. Pest Management Regulatory Agency Regulatory. Proposed Acceptability for

Continuing Registration PACR2005-01, Re-evaluation of the Lawn and Turf Uses of (2,4-

Dichlorophenoxy)acetic Acid[2,4-D]

1293704 Canada, 2006. Pest Management Regulatory Agency Regulatory. Re-evaluation Note REV2006-11,

Lawn and Turf Uses of (2,4-Dichlorophenoxy)acetic Acid [2,4-D]: Interim Measures

1434680 Canada, 2007. Pest Management Regulatory Agency Regulatory. Proposed Acceptability for

Continuing Registration PACR 2007-06, Re-evaluation of the Agricultural, Forestry, Aquatic and

Industrial Site Uses of (2,4-Dichlorophenoxy)acetic Acid [2,4-D]

1604212 Canada, 2008. Pest Management Regulatory Agency Regulatory. Re-evaluation Decision, RVD2008-

11, (2,4-Dichlorophenoxy)acetic Acid [2,4-D], 16 May 2008

2405939 Canada, 2013a. Pest Management Regulatory Agency Regulatory Note REV2013-06, Special Review

Initiation of 23 Active Ingredients

2254850 Canada, 2013b. Pest Management Regulatory Agency Regulatory. Re-evaluation Note, REV2013-02,

Re-evaluation update 2,4-D

2617375 European Commission, 2014. Conclusion on the peer review of the pesticide risk assessment of the

active substance 2,4-D. EFSA Journal 12(9):3812

2617381 Rotterdam Convention, 2001. PIC Circular XIII. June 2001

2627416 Loomis D., Guyton K., Grosse Y., El Ghissassi F., Bouvard V. 2015. Carcinogenicity of lindane,

DDT, and 2,4-dichlorophenoxyacetic acid. Lancet Oncology Vol. 16: 891-892

2617383 United States, 2014. Response to Public Comments Received Regarding New Uses of Enlist DuoTM

on Corn and Soybeans. United States Environmental Protection Agency, Office of Chemical Safety

and Pollution Prevention, October 2014.

2617376 Burns C.J. and Swaen G.M.H (2012) Review of 2,4-dichlorophenoxyacetic acid (2,4-D) biomonitoring

and epidemiology. Crit. Rev. Toxicol. 42(9):768-786

2617379 Ntzani EE, Chondrogiorgi M, Ntritsos G, Evangelou E, Tzoulaki I, 2013. Literature review on

epidemiological studies linking exposure to pesticides and health effects. EFSA supporting publication

2013: EN-497, 159 pp. Available online: www.efsa.europa.eu/publications

2617380 Pahwa M., Harris S.A., Hohenadel K., McLaughlin J.R., Spinelli J.J., Pahwa P., Dosman J.A., and

Blair A. (2012) Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in

Canadian men in six provinces. Int. J. Cancer 131:2650-2659

2617382 Schinasi L. and Leon M.E. (2014) Non-Hodgkin lymphoma and occupational exposure to agricultural

pesticide chemical groups and active ingredients: a systemic review and meta-analysis. Int. J .Environ.

Res. Pub Health 11:4449-4527

2617384 von Stackelberg K. (2013) A systemic review of carcinogenic outcomes and potential mechanisms

from exposure to 2,4-D and MCPA in the environment. J. Toxicol. 2013: 1-53

2617385 Weichenthal S., Moase C., and Chan P. (2010) A review of pesticide exposure and cancer incidence in

the agricultural health study cohort. Environ. Health Persp. 118: 1117-1125

1307560 Struger, J, T. Fletcher And G. Gris, 2004, Occurrence Of Pesticides In The Don And Humber River

Watersheds (1998 - 2002), Interm Report, Environment Canada, Ontario Ministry Of The

Environment And The City Of Toronto, DACO: 8.6

References

Re-evaluation Note - REV2016-08

Page 18

PMRA

Number

Reference

1311123 2005, Direction Du Suivi De L'etat De L'environnement; Developpement Durable, Environnement Et

Parcs Quebec, Les Pesticides Utilises Dans Les Espaces Verts Urbains; Presence Dans L'eau Des

Rejets Urbains Et Dans L'air Ambiant, Blibiotheque national du Quebec, ISBN 2-550-44907-X,

Envirodoq No ENV/2005/0165, DACO: 8.6

1311142 Byrtus Gary et al., 2004, Alberta Environment, Environmental Assuaranc Service, A Summary Of

Pesticide Residues From The Alberta Treated Water Survey, 1995 - 2003., A Summary Of Pesticide

Residue Data, Alberta Environment, Environmental Assurance Service, DACO: 8.6

1311143 Alberta Environment, Environmental Assurance Service, A Summary Of Pesticide Residues From The

Alberta Treated Water Survey, 1995 - 2003. Raw Data, DACO: 8.6

1398444 Les pesticides en milieu agricole: etat de la situation environnementale et initiatives prometteuses.

Direction des politiques en milieu terrestre, Service des pesticides, Ministere du Developpement

durable, de l'Environnement et des Parcs, Quebec. http://www.mddep.gouv.qc.ca/pesticides/etat-

env/etat-env.pdf, DACO: 8.6

1398451 Giroux, I. et al, 2006, Ministere du Developpement durable, de l'Environnement et des Parcs,

Direction du suivi de l'etat de l'environnement, Direction des politiques de l'eau et Centre d'expertise

en analyse environnementale du Quebec., Part 1: La presence de pesticides dans l'eau au Quebec,

Bilan dans les cours d'eau de zones en culture de mais et de soya en 2002, 2003 et 2004 et dans les

reseaux de distribution d'eau potable., http://www.mddep.gouv.qc.ca/pesticides/mais_soya/index.htm,

DACO: 8.6

1398452 Giroux, I. et al, 2006, Part 2: La presence de pesticides dans l'eau au Quebec, Bilan dans les cours

d'eau de zones en culture de mais et de soya en 2002, 2003 et 2004 et dans les reseaux de distribution

d'eau potable. Ministere du Developpement durable, de l'Environnement et des Parcs, Direction du

suivi de l'etat de l'environnement, Direction des politiques de l'eau et Centre d'expertise en analyse

environnementale du Quebec., http://www.mddep.gouv.qc.ca/pesticides/mais_soya/index.htm, DACO:

8.6

1398453 Giroux, I. et al, 2006, Part 3: La presence de pesticides dans l'eau au Quebec, Bilan dans les cours

d'eau de zones en culture de mais et de soya en 2002, 2003 et 2004 et dans les reseaux de distribution

d'eau potable. Ministere du Developpement durable, de l'Environnement et des Parcs, Direction du

suivi de l'etat de l'environnement, Direction des politiques de l'eau et Centre d'expertise en analyse

environnementale du Quebec., http://www.mddep.gouv.qc.ca/pesticides/mais_soya/index.htm, DACO:

8.6

1723616 Giroux, I., 2007, Giroux, I. 2007. Les pesticides dans quelques tributaires de la rive nord du Saint-

Laurent: Riviere L'Assomption, Bayonne, Maskinonge et du Loup. Ministere du Developpement

durable, de l'Environnement et des Parcs. Direction du suivi de l'etat de l'environnement. DACO: 8.6

1723625 Marchand, S. and R. Asselin., 2006, Marchand, S. and R. Asselin. 2006. Caracterisation des effluents

des fermes de canneberges. Club d'encadrement technique Atocas Quebec (CETAQ), ministere de

l'Agriculture, des Pecheries et de l'Alimentation, Direction regionale du Centre-du-Quebec. 68 p.,

DACO: 8.6

1739314 Harris, K. A, et al., 2008, Partitioning of Current-use and Legacy Pesticides in Salmon Habitat in

British Columbia, Canada. Environmental Toxicology and Chemistry 27(11): 2253-2262., DACO: 8.6

1758182 Donald, D.B., Cessna, A.J., Sverko, E., Glozier, N.E., 2007, Pesticides in surface drinking-water

supplies of the Northern Great Plains. This is a summary of Pesticide Science Fund data. Environment

Canada, Agriculture and Agri-Food Canada, Environmental Health Perspectives, VOLUME 115,

NUMBER 8, August 2007, DACO: 8.6

2505828 United States Department of Agriculture (USDA). 2013 Pesticide Data Program Annual Summary,

Calendar Year 2013, Science and Technology Programs, USDA, DACO: 8.6, DACO: 8.6

References

Re-evaluation Note - REV2016-08

Page 19

PMRA

Number

Reference

2505827 United States Department of Agriculture (USDA). 2012. Pesticide Data Program Annual Summary,

Calendar Year 2012, Science and Technology Programs, USDA, DACO: 8.6

2312780 United States Department of Agriculture (USDA). 2013. Pesticide Data Program Annual Summary,

Calendar Year 2011. Science and Technology Programs, USDA. February 2013., DACO: 8.6

2312778 United States Department of Agriculture (USDA). 2012. Pesticide Data Program Annual Summary,

Calendar Year 2010. Science and Technology Programs, USDA. May 2012., DACO: 8.6

2312776 United States Department of Agriculture (USDA). 2011. Pesticide Data Program Annual Summary,

Calendar Year 2009. Science and Technology Programs, USDA. May 2011., DACO: 8.6

1852614 United States Department of Agriculture (USDA). 2009. Pesticide Data Program Annual Summary,

Calendar Year 2008. Science and Technology Programs, USDA. December 2009., DACO: 8.6

1774484

1957282

Pesticide Data Program Annual Summary, Calendar Year 2007. United States Department of

Agriculture (USDA), Science and Technology Programs., USDA 2007. Science and Technology

Programs. United States Department of Agriculture., DACO: 8.6

1852619 United States Department of Agriculture (USDA). 2007. Pesticide Data Program Annual Summary,

Calendar Year 2006. Science and Technology Programs,Agricultural Marketing Service, USDA.

December 2007., DACO: 8.6

1852618 United States Department of Agriculture (USDA). 2006. Pesticide Data Program Annual Summary,

Calendar Year 2005. Science and Technology Programs, Agricultural Marketing Service, USDA.

November 2006., DACO: 8.6

1852616 United States Department of Agriculture (USDA). 2006. Pesticide Data Program Annual Summary,

Calendar Year 2004. Science and Technology Programs, Agricultural Marketing Service, USDA.

February 2006., DACO: 8.6

1857388 United States Department of Agriculture (USDA). 2005. Pesticide Data Program Annual Summary,

Calendar Year 2003. Science and Technology Programs, Agricultural Marketing Service, USDA. June

2005., DACO: 8.6

1857396 United States Department of Agriculture (USDA). 2004. Pesticide Data Program Annual Summary,

Calendar Year 2002. Science and Technology Programs, Agricultural Marketing Service, USDA.

February 2004., DACO: 8.6

2035772 Pesticides dans l’eau de surface d’une zone maraichere Ruisseau Gibeault-Delisle dans les « terres

noires » du bassin versant de la riviere chateauguay de 2005 a 2007 Juin 2010, DACO: 8.6

2102602 Giroux, I., 2010, Presence de pesticides dans l'eau au Quebec - Bilan dans quatre cour d'eau de zones

en culture de mais et de soya en 2005, 2006 et 2007 et dans des reseaux de distribution d'eau potable,

DACO: 8.6

2306368 Giroux, I. and L. Pelletier, Presence de pesticides dans l'eau du Quebec : bilan dans quatre cours d'eau

de zones en culture de mais et de soya en 2008, 2009 et 2010, DACO: 8.6

2428525 Todd, A. and J. Struger. 2014. Changes in acid herbicide concentrations in urban streams after a

cosmetic pesticides ban. Challenges 5:138-151, DACO: 8.6

2506289 Woudneh, M.B. et. Al., 2007.Acidic herbicides in surface waters of Lower Fraser Valley, British

Columbia, Canada Journal Of Chromatography A,1139, 121-129., DACO: 8.6

References

Re-evaluation Note - REV2016-08

Page 20

Unpublished Information

PMRA

Number

Reference

2617378 Norway, 1991. Ecotoxicological Documentation 2,4-D-Di-Salt, November 1991

2617400 Norway, 1997. Minute book, Board of Pesticides (Rådet for plantevernsmidler ): Case 16/97:

Weedar 64- 2,4 D, application for renewed approval, File no. 33/96

2617377 Rotterdam Convention. Form for Notification of the Final Regulatory Action to Ban or Severely

Restrict a Chemical. Country: Norway.

1311107 Unpublished water monitoring data collected in reservoirs of the Prairie Region (2003 - 2004).

Pesticide Science Fund.,DACO: 8.6

1311110 Environment Canada, Presence, Levels and Relative Risks of Priority Pesticides in selected

Canadian aquatic ecosystems: an Environment Canada Pesticides Science Fund Project. year 1

(2003-04) Annual Report, DACO: 8.6

1311111 Environment Canada, Unpublished Pesticide Science Fund Annual Report 2004-2005. (water, air,

plants, mammals and amphibians; and fish and birds)., DACO: 8.6

1311112 Environment Canada, Unpublished National Water Monitoring Data. Pesticide Science Fund

(2004)., DACO: 8.6

1311116 Environment Canada, Unpbulished Water Monitoring Data collected in Wetlands of the Prairie

Region (2004). Pesticide Science Fund, DACO: 8.6

1311131 Manitoba Water Stewardship, Unpublished Water Monitoring Data from Manitoba (2001 - 2003),

DACO: 8.6

1357366 Unpublished Water Monitoring Data Collected from Great Lakes Area of Concern and Small

Streams in the Niagara and Burlington Area (2003). Part of the Pesticide Science Fund., DACO:

8.6

1357367 Unpublished Water Monitoring Data Collected from Great Lakes Area of Concern (2004). Part of

the Pesticide Science Fund., DACO: 8.6

1357368 Unpublished Water Monitoring Data Collected from Great Lakes Area of Concern and Great Lakes

Connecting Channels (2002), DACO: 8.6

1357369 Unpublished Water Monitoring Data Collected From Lake Huron Tributaries (2002), DACO: 8.6

1398447 Unpublished Water and Suspended Sediment Monitoring Data from the Peel River Yukon/NWT,

DACO: 8.6

1403269 Environment Canada, Pesticide Science Fund Annual Report 2005-2006., DACO: 8.6

1560632 Pesticide Sampling Program for Selected Municipal Drinking Water Supplies in New Brunswick.:

Tables 4-6: Results by Municipality and QA/QC Samples DACO: 8.6

1703707 Environment Canada (2008) Unpublished water monitoring data on 2,4-DB, (2002-2006), provided

by Environment Canada, Ontario Region., DACO: 8.6

1726638 Pesticide Science Fund Annual Report 2006-2007; DACO: 8.6, 9.9

1726642 Pesticide Science Fund Annual Report 2007-2008; DACO 8.6

1971119 Raw Unpublished Pesticide Science Fund Water Monitoring from Mill Creek British Columbia,

DACO: 8.6

2170918 Nova Scotia Department of the Environment. (2009). Unpublished municipal groundwater

monitoring data. Received June 2011, Nova Scotia Department of the Environment. (2009).

Unpublished municipal groundwater monitoring data. Received June 2011., DACO: 8.6

References

Re-evaluation Note - REV2016-08

Page 21

PMRA

Number

Reference

2171036 Ontario Ministry of the Environment. (2010). Unpublished groundwater monitoring data from

Ontario’s Provincial Groundwater Monitoring Network. Received September 2011., DACO: 8.6

2149078 Elliott, J. et al., 2011, (2010). Groundwater vulnerability to pesticide contamination in the

Assiniboine Delta Aquifer. Environment Canada Pesticide Science Fund, DACO: 8.6

2408645 Saskatchewan Water Security Agency. 2014. Water monitoring data on 2,4-D submitted following

the PMRA's February 2014 monitoring data request for active ingredients under special review.

Data submitted February 27, 2014. Government of Saskatchewan, DACO: 8.6

2408702 Government of Alberta. 2014. Monitoring data for 2.4-D in Alberta's treated water supply shared

by Health Canada's Water Quality & Science Bureau following the PMRA's February 2014

monitoring data request for active ingredients under special review. Data submitted February 19,

2014, DACO: 8.6

2408703 Government of New Brunswick. 2014. Report on 2,4-D in New Brunswick municipal drinking

water sources shared by Health Canada's Water Quality & Science Bureau following the PMRA's

February 2014 monitoring data request for active ingredients under special review. Report

submitted February 19, 2014, DACO: 8.6

2408707 Government of Quebec. 2014. Monitoring data on 2,4-D in drinking water supplies in Quebec

shared by Health Canada's Water Quality & Science Bureau following the PMRA's February 2014

monitoring data request for active ingredients under special review. Report submitted February 19,

2014, DACO: 8.6

2408708 Government of Saskatchewan. 2014. Monitoring data on 2,4-D in drinking water supplies in

Saskatchewan shared by Health Canada's Water Quality & Science Bureau following the PMRA's

February 2014 monitoring data request for active ingredients under special review. Report

submitted February 19, 2014, DACO: 8.6

2413008 MDDEPF. 2014. Monitoring data on 2,4-D in surface water and groundwater submitted following

the PMRA's February 2014 monitoring data request for active ingredients under special review.

Data submitted April 15, 2014. Banque de donnees sur la qualite du milieu aquatique (BQMA),

Quebec, ministere du Developpement durable, de l'Environnnement, de la Faune et des Parcs.

Direction du suivi de l'etat de l'environnement, DACO: 8.6

2413013 MDDEFP. 2014. Monitoring data on 2,4-D (and other pesticides) in raw surface water prior to

entry in drinking water treatment station and in treated water submitted following the PMRA's

February 2014 monitoring data request for active ingredients under special review. Data submitted

April 15, 2014. Banque de donnees sur la qualite du milieu aquatique (BQMA), Quebec, ministere

du Developpement durable, de l'Environnement, de la Faune et des Parcs. Direction du suivi de

l'etat de l'environnement, DACO: 8.6

2413016 MDDEPF. 2014. Monitoring data on 2,4-D in drinking water submitted following the PMRA's

February 2014 monitoring data request for active ingredients under special review. Data submitted

April 15, 2014. Banque de donnees sur la qualite du milieu aquatique (BQMA), Quebec, ministere

du Developpement durable, de l'Environnnement, de la Faune et des Parcs. Direction du suivi de

l'etat de l'environnement, DACO: 8.6

2424839 Part 1: Environment Canada. 2007. Surveillance of Pesticide Residues in Surface Water in an

Intensive Agricultural Region of Northwestern New Brunswick - 2006. Internal Monitoring Project

Report. A Cooperative Project by Environment Canada, Agriculture and Agri-Food Canada and the

New Brunswick Department of Environment and Local Governments. A Pesticides Science Fund

Project. December 2007., DACO: 8.6

References

Re-evaluation Note - REV2016-08

Page 22

PMRA

Number

Reference

2424841 Part 2: Environment Canada. 2007. Surveillance of Pesticide Residues in Surface Water in an

Intensive Agricultural Region of Northwestern New Brunswick - 2006. Internal Monitoring Project

Report. A Cooperative Project by Environment Canada, Agriculture and Agri-Food Canada and the

New Brunswick Department of Environment and Local Governments. A Pesticides Science Fund

Project. December 2007., DACO: 8.6

2424873 Saskatchewan Water Security Agency.2014. Water monitoring data on 2,4-D submitted following

the PMRA's April 2014 monitoring data request for active ingredients under special review. Data

submitted May 1, 2014. Government of Saskatchewan., DACO: 8.6

2428526 Challenges 5:138-151, Todd, A. and J. Struger. 2014. Unpublished supplemental information to the

published article: Changes in acid herbicide concentrations in urban streams after a cosmetic

pesticides ban. Challenges 5:138-151, DACO: 8.6

2430948 Ontario Ministry of the Environment and Ontario Ministry of Agriculture. 2014. Water monitoring

data on 2,4-D in surface water from Ontario submitted following the PMRA's April 2014

monitoring data request for active ingredients under special review. Data submitted May 29, 2014.,

DACO: 8.6

2430952 Ontario Ministry of the Environment. 2014. Water monitoring data on 2,4-D in groundwater from

the Ontario Provincial Groundwater Monitoring Network submitted following the PMRA's April

2014 monitoring data request for active ingredients under special review. Data submitted May 29,

2014., DACO: 8.6

2430953 Ontario Ministry of the Environment. 2014. Water monitoring data on 2,4-D in Ontario urban

streams submitted following the PMRA's April 2014 monitoring data request for active ingredients

under special review. Data submitted May 29, 2014., DACO: 8.6

2430958 Government of British Columbia. 2014. Responses from the Government of British Columbia

following the PMRA's April 2014 request for monitoring data request for active ingredients under

special review. Monitoring information on 2,4-D received May 28, 2014, DACO: 8.6

2462785 Ontario Ministry of the Environment and Climate Change. 2014. Monitoring data on 2.4-D in

Ontario raw water and treated drinking water. Submitted following the PMRA's April 2014

monitoring data request for active ingredients under special review. Data submitted September 19,

2014., DACO: 8.6

2483901 Water Quality Management Section, Manitoba Conservation and Water Stewardship. 2014.

Monitoring data for 2,4-D received following the PMRA's December 2014 request for monitoring

data for active ingredients under special review. 123 Main Street, Suite 160, Winnipeg MB R3C

1A5, Data received December 15, 2014, DACO: 8.6

2505509 California Department of Pesticide Regulation. 2015. Surface Water Protection Program data for

2,4-D. Downloaded on February 12, 2015.

https://www.google.com/fusiontables/DataSource?snapid=S954602gmYX, DACO: 8.6

2509897 United States Geological Survey. 2015. USGS National Water Quality Assessment (NAWQA)

program water monitoring for 2,4-D, form 2002 to 2015. Downloaded March 6, 2015.

http://water.usgs.gov/nawqa/ DACO: 8.6

2509899 United States Environmental Protection Agency. 2015. Monitoring data for 2,4-D in water from

2002 to 2015 downloaded from the US EPA Storage and Retrieval (STORET) data warehouse on

February 19, 2015. http://ofmpub.epa.gov/storpubl/dw_pages.querycriteria, DACO: 8.6