National Institutes of Health Clinical Center
HAZARDOUS DRUG LIST
P&T Approved: March 28, 2019
Background
This list defines drugs that both the National Institute for Occupational Safety and Health (NIOSH) as well as the NIH Clinical Center
(based on an internal hazard safety assessment) considers hazardous and require extra safety precautions for handling, preparation,
and administration in the health care setting. These precautions may vary with drug formulation/dosage form and route of
administration.
NIOSH categorizes hazardous drugs into 3 groups:
Group 1
Antineoplastic medications
Group 2
Non-antineoplastic drugs that meet one or more NIOSH criteria for a hazardous drug (Note: some of these drugs may also
pose a reproductive risk for susceptible populations)
Group 3
Drugs that primarily pose a reproductive risk to men and women who are actively trying to conceive and women who are
pregnant or breastfeeding
Acronyms
CSTD = closed system drug-transfer device
PPE = personal protective equipment
Citation
NIOSH [2016]. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2016. By Connor TH, MacKenzie BA, DeBord DG,
Trout DB, O’Callaghan JP. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National
Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2016-161 (Supersedes 2014-138).
Page 1 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
abacavir
Ziagen
Oral tablet
F
Single chemotherapy gloves
abacavir
Ziagen
Oral solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
abacavir/lamivudine
Epzicom
Oral tablet
F
Single chemotherapy gloves
abacavir/dolutegravir/lamivudine
Triumeq
Oral tablet
F
Single chemotherapy gloves
abacavir/lamivudine/zidovudine
Trizivir
Oral tablet
NF
Single chemotherapy gloves
abiraterone acetate
Zytiga
Oral tablet
NF
Single chemotherapy gloves
acitretin
Soriatane
Oral capsule
NF
Single chemotherapy gloves
ado-trastuzumab emtansine
Kadcyla
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
afatinib
Gilotrif
Oral tablet
NF
Single chemotherapy gloves
alitretinoin
Panretin
Topical gel/jelly
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
ambrisentan
Letairis
Oral tablet
F
Single chemotherapy gloves
anastrozole
Arimidex
Oral tablet
F
Single chemotherapy gloves
apomorphine
Apokyn
Subcutaneous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
arsenic trioxide
Trisenox
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
axitinib
Inlyta
Oral tablet
NF
Single chemotherapy gloves
azaCITIDine
Vidaza
Suspension for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
azaTHIOprine
Imuran; Azasan
Oral tablet
F
Single chemotherapy gloves
azaTHIOprine
N/A
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 2 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
Bacillus Calmette Guerin (BCG)
vaccine
Tice BCG
Percutaneous powder for solution;
intravesical powder for suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
belinostat
Beleodaq
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
bendamustine
Treanda, Bendeka
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
bevacizumab
Avastin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
bexarotene
Targretin
Oral capsule
NF
Single chemotherapy gloves
bexarotene
Targretin
Topical gel/jelly
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
bicalutamide
Casodex
Oral tablet
F
Single chemotherapy gloves
bleomycin
Blenoxane
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
blinatumomab
Blincyto
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
bortezomib
Velcade
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
bosentan
Tracleer
Oral tablet
F
Single chemotherapy gloves
bosentan
Tracleer
Oral tablet for suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
bosutinib
Bosulif
Oral tablet
NF
Single chemotherapy gloves
Page 3 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
botulinum toxins, all forms
Dysport, Xeomin, Botox,
Myobloc
Intramuscular injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
brentuximab vedotin
Adcetris
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
brigatinib
Alunbrig
Oral tablet
NF
Single chemotherapy gloves
busulfan
Myleran
Oral tablet
F
Single chemotherapy gloves
busulfan
Busulfex
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cabazitaxel
Jevtana
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cabergoline
N/A
Oral tablet
F
Single chemotherapy gloves
cabozantinib
Cabometyx; Cometriq
Oral tablet; oral capsule
NF
Single chemotherapy gloves
capecitabine
Xeloda
Oral tablet
F
Single chemotherapy gloves
carBAMazepine
Carbatrol, Equetro, Epitol,
Tegretol
Oral tablet; oral capsule
F
Single chemotherapy gloves
carBAMazepine
Tegretol
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
CARBOplatin
Paraplatin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
carfilzomib
Kyprolis
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
carmustine
BiCNU; Gliadel Wafer
Intravenous solution; implant wafer
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ceritinib
Zykadia
Oral capsule
NF
Single chemotherapy gloves
Page 4 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
cetrorelix
Cetrotide
Subcutaneous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
chlorambucil
Leukeran
Oral tablet
F
Single chemotherapy gloves
chloramphenicol
Chloromycetin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
chorionic gonadotropin, human
Novarel, Pregnyl
Intramuscular solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
chorionic gonadotropin,
recombinant
Ovidrel
Subcutaneous solution for injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cidofovir
Vistide
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
CISplatin
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cladribine
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cloBAZam
Onfi
Oral tablet
F
Single chemotherapy gloves
cloBAZam
Onfi
Oral suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
clofarabine
Clolar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
clomiPHENE
N/A
Oral tablet
F
Single chemotherapy gloves
clonazePAM
KlonoPIN
Oral tablet
F
Single chemotherapy gloves
cobimetinib
Cotellic
Oral tablet
NF
Single chemotherapy gloves
colchicine
Colcrys; Mitigare
Oral tablet; oral capsule
F
Single chemotherapy gloves
Page 5 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
crizotinib
Xalkori
Oral capsule
NF
Single chemotherapy gloves
cyclophosphamide
N/A
Oral capsule; oral tablet
F
Single chemotherapy gloves
cyclophosphamide
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cycloSPORINE
Gengraf, Neoral, Sandimmune
Oral capsule
F
Single chemotherapy gloves
cycloSPORINE
Gengraf, Neoral, Sandimmune
Oral solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
cycloSPORINE
Sandimmune
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
cycloSPORINE
Restasis
Ophthalmic emulsion
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
cytarabine (conventional)
N/A
Injection solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
dabrafenib
Tafinlar
Oral capsule
NF
Single chemotherapy gloves
dacarbazine
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
DACTINomycin
Cosmegen
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
darbepoetin alfa
Aranesp
Intravenous/subcutaneous solution for
injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
dasatinib
Sprycel
Oral tablet
F
Single chemotherapy gloves
DAUNOrubicin (conventional)
Cerubidine
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 6 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
decitabine
Dacogen
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
deferiprone
Ferriprox
Oral tablet
NF
Single chemotherapy gloves
deferiprone
Ferriprox
Oral solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
degarelix
Firmagon
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
desflurane
Suprane
Solution for inhalation
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
dexrazoxane
Zinecard
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
dihydroergotamine
D.H.E. 45
Solution for injection (IV, IM, SC)
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
dihydroergotamine
Migranal
Nasal spray
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
dinoprostone
Cervidil; Prepidil; Prostin E2
Vaginal insert; vaginal gel/jelly; vaginal
suppository
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
divalproex
Depakote; Depakote ER;
Depakote Sprinkles; Depakote
DR
Oral tablet; oral capsule
F
Single chemotherapy gloves
Page 7 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
DOCEtaxel
Taxotere
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
DOXOrubicin (conventional)
Adriamycin
Intravenous solution;
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
DOXOrubicin (liposomal)
Doxil
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
dronedarone
Multaq
Oral tablet
F
Single chemotherapy gloves
dutasteride
Avodart
Oral capsule
NF
Single chemotherapy gloves
enasidenib
IDHIFA
Oral tablet
NF
Single chemotherapy gloves
entecavir
Baraclude
Oral tablet
F
Single chemotherapy gloves
entecavir
Baraclude
Oral solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
enzalutamide
Xtandi
Oral capsule
F
Single chemotherapy gloves
epiRUBicin
Ellence
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
eriBULin mesylate
Halaven
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
erlotinib
Tarceva
Oral tablet
F
Single chemotherapy gloves
eslicarbazepine acetate
Aptiom
Oral tablet
F
Single chemotherapy gloves
estradiol
many branded & generic
products such as Estring;
EstroGel; Evamist
Oral tablet
F
Single chemotherapy gloves
estradiol
many branded & generic
products such as Estring,
Vagifem
Vaginal tablet; vaginal cream; vaginal insert
ring; transdermal patch; transdermal gel/jelly;
topical gel/jelly; transdermal spray
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
estradiol/norethindrone
CombiPatch
Transdermal patch
F
Double chemotherapy gloves
Protective gown
estramustine
Emcyt
Oral capsule
F
Single chemotherapy gloves
Page 8 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
estrogen; conjugated
Premarin
Oral tablet
F
Single chemotherapy gloves
estrogen; conjugated
Premarin
Vaginal cream
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
estrogen; conjugated
Premarin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
estrogen (esterified)
Menest
Oral tablet
NF
Single chemotherapy gloves
estrogen (conjugated) and
medroxyprogesterone
Prempro
Oral tablet
F
Single chemotherapy gloves
estropipate
Ogen .625; Ogen 1.25; Ogen
2.5; Ortho-Est
Oral tablet
NF
Single chemotherapy gloves
ethinyl estradiol/ethynodiol
diacetate
Zovia; Kelnor
Oral tablet
F
Single chemotherapy gloves
ethinyl estradiol/levonorgestrel
Enpresse; Jolessa
Oral tablet
F
Single chemotherapy gloves
ethinyl estradiol/norelgestromin
Xulane
Transdermal patch
F
Double chemotherapy gloves
Protective gown
ethinyl estradiol/norethindrone
Loestrin FE; Migrogestin FE
Oral tablet
F
Single chemotherapy gloves
ethinyl estradiol/norgestrel
Low-Ogestrel
Oral tablet
F
Single chemotherapy gloves
etonogestrel
Nexplanon
Subcutaneous Implant
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
etoposide
N/A
Oral capsule
F
Single chemotherapy gloves
etoposide
Toposar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
etoposide phosphate
Etopophos
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
everolimus
Afinitor; Zortress
Oral tablet
NF
Single chemotherapy gloves
everolimus
Afinitor; Zortress
Oral tablet for suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
exemestane
Aromasin
Oral tablet
NF
Single chemotherapy gloves
Page 9 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
exenatide
Byetta, Bydureon
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
finasteride
Propecia; Proscar
Oral tablet
NF
Single chemotherapy gloves
fingolimod
Gilenya
Oral capsule
NF
Single chemotherapy gloves
floxuridine
N/A
Solution for injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
fluconazole
Diflucan
Oral tablet
F
Single chemotherapy gloves
fluconazole
Diflucan
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
fluconazole
Diflucan
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
flucytosine
Ancobon
Oral capsule
F
Single chemotherapy gloves
fludarabine
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
fluorouracil
Adrucil
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
fluorouracil
Carac, Efudex, Fluoroplex,
Tolak
Topical cream; topical solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
flutamide
N/A
Oral capsule
F
Single chemotherapy gloves
fosphenytoin
Cerebyx
Injection solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
fulvestrant
Faslodex
Intramuscular solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 10 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
ganciclovir
Cytovene
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ganciclovir
Zirgan
Ophthalmic gel/jelly
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
ganirelix
N/A
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
gemcitabine
Gemzar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
gemtuzumab ozogamicin
Mylotarg
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
goserelin
Zoladex
Subcutaneous implant
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
histrelin
Supprelin LA, Vantas
Subcutaneous implant
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
hydroxyurea
Droxia; Hydrea
Oral capsule
F
Single chemotherapy gloves
icatibant
Firazyr
Subcutaneous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
IDArubicin
Idamycin PFS
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ifosfamide
Ifex
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 11 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
imatinib
Gleevec
Oral tablet
F
Single chemotherapy gloves
inotuzumab ozogamicin
Besponsa
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
interferon beta-1b
Betaseron, Extavia
Subcutaneous injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
irinotecan (conventional)
Camptosar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
irinotecan (liposomal)
Onivyde
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
isoflurane
Forane, Terrell
Solution for inhalation
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
ISOtretinoin
Absorica, Amnesteem,
Claravis, Myorisan, Zenatane
Oral capsule
F
Single chemotherapy gloves
ivabradine
Corlanor
Oral tablet
F
Single chemotherapy gloves
ixabepilone
Ixempra Kit
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ixazomib
Ninlaro
Oral capsule
NF
Single chemotherapy gloves
lapatinib
Tykerb
Oral tablet
NF
Single chemotherapy gloves
leflunomide
Arava
Oral tablet
F
Single chemotherapy gloves
lenalidomide
Revlimid
Oral capsule
F
Single chemotherapy gloves
lenvatinib
Lenvima
Oral capsule
NF
Single chemotherapy gloves
letrozole
Femara
Oral tablet
F
Single chemotherapy gloves
leuprolide
Lupron, Lupron Depot
Subcutaneous suspension; intramuscular
suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
levonorgestrel
Aftera, EContra, Plan B
Oral tablet
F
Single chemotherapy gloves
levonorgestrel
Mirena
Intrauterine device
F
Double chemotherapy gloves
Protective gown
Page 12 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
lomitapide
Juxtapid
Oral capsule
NF
Single chemotherapy gloves
lomustine
Gleostine
Oral capsule
NF
Single chemotherapy gloves
macitentan
Opsumit
Oral tablet
NF
Single chemotherapy gloves
mechlorethamine
Mustargen
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
mechlorethamine
Valchlor
Topical gel
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
medroxyPROGESTERone
Provera
Oral tablet
F
Single chemotherapy gloves
medroxyPROGESTERone
Depo-Provera
Intramuscular suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
megestrol
Megace
Oral tablet
F
Single chemotherapy gloves
megestrol
Megace
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
melphalan
Alkeran
Oral tablet
F
Single chemotherapy gloves
melphalan
Alkeran; Evomela
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
menotropins
Menopur
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
mercaptopurine
Purinethol
Oral tablet
F
Single chemotherapy gloves
mercaptopurine
Purixan
Oral suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
methIMAzole
Tapazole
Oral tablet
F
Single chemotherapy gloves
methotrexate
Trexall
Oral tablet
F
Single chemotherapy gloves
methotrexate
Xatmep
Oral solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
Page 13 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
methotrexate
N/A
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
methotrexate
Otrexup, Rasuvo
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
methoxsalen
Oxsoralen Ultra
Oral capsule
NF
Single chemotherapy gloves
methoxsalen
Uvadex
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
methylergonovine
Methergine
Oral tablet
F
Single chemotherapy gloves
methylergonovine
N/A
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
methylTESTOSTERone
Methitest
Oral tablet; oral capsule
NF
Single chemotherapy gloves
midostaurin
Rydapt
Oral capsule
F
Single chemotherapy gloves
miFEPRIStone
Korlym; Mifeprex
Oral tablet
NF
Single chemotherapy gloves
Miltefosine
Impavido
Oral capsule
NF
Single chemotherapy gloves
mipomersen
Kynamro
Subcutaneous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
miSOPROStol
Cytotec
Oral tablet
NF
Single chemotherapy gloves
mitoMYcin
Mutamycin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
mitotane
Lysodren
Oral tablet
F
Single chemotherapy gloves
mitoXANTRONE
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
mycophenolate mofetil
CellCept
Oral tablet; oral capsule
F
Single chemotherapy gloves
mycophenolate mofetil
CellCept
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
Page 14 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
mycophenolate mofetil
CellCept
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
mycophenolic acid
Myfortic
Oral tablet
NF
Single chemotherapy gloves
nafarelin
Synarel
Nasal spray
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
nelarabine
Arranon
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
nevirapine
Viramune
Oral tablet
F
Single chemotherapy gloves
nevirapine
Viramune
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
nilotinib
Tasigna
Oral capsule
F
Single chemotherapy gloves
norethindrone
Camila; Ortho Micronor
Oral tablet
F
Single chemotherapy gloves
olaparib
Lynparza
Oral capsule; oral tablet
NF
Single chemotherapy gloves
omacetaxine
Synribo
Subcutaneous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
osimertinib
Tagrisso
Oral tablet
NF
Single chemotherapy gloves
ospemifene
Osphena
Oral tablet
NF
Single chemotherapy gloves
oxaliplatin
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
OXcarbazepine
Trileptal
Oral tablet
F
Single chemotherapy gloves
OXcarbazepine
Trileptal
Oral suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
oxytocin
Pitocin
Solution for injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 15 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
PACLitaxel (conventional)
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
PACLitaxel (protein bound)
Abraxane
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
palifermin
Kepivance
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
pamidronate
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
panobinostat
Farydak
Oral capsule
NF
Single chemotherapy gloves
PARoxetine
Brisdelle; Paxil; Paxil CR;
Pexeva
Oral tablet; oral capsule
F
Single chemotherapy gloves
PARoxetine
Paxil
Oral suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
pasireotide
Signifor; Signifor LAR
Intramuscular suspension; subcutaneous
solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
PAZOPanib
Votrient
Oral tablet
NF
Single chemotherapy gloves
PEMEtrexed
Alimta
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
pentamidine
Pentam
Solution for injection; solution for inhalation
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required (if intravenous)
Respiratory protection (if inhalation)
pentetate calcium trisodium
diethylene triamine penta-
acetic acid
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 16 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
pentostatin
Nipent
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
pertuzumab
Perjeta
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
phenoxybenzamine
Dibenzyline
Oral capsule
F
Single chemotherapy gloves
phenytoin
Dilantin; Dilantin Infatabs
Oral tablet, oral capsule
F
Single chemotherapy gloves
phenytoin
Dilantin
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
phenytoin
N/A
Injection solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
plerixafor
Mozobil
Subcutaneous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
pomalidomide
Pomalyst
Oral capsule
NF
Single chemotherapy gloves
PONATinib
Iclusig
Oral tablet
NF
Single chemotherapy gloves
porfimer
Photofrin
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
PRALAtrexate
Folotyn
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
procarbazine
Matulane
Oral capsule
NF
Single chemotherapy gloves
progesterone
Prometrium
Oral capsule
F
Single chemotherapy gloves
progesterone
N/A
Intramuscular oil
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 17 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
progesterone
Crinone; Endometrin
Vaginal gel; vaginal insert
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
propylthiouracil
N/A
Oral tablet
F
Single chemotherapy gloves
raloxifene
Evista
Oral tablet
NF
Single chemotherapy gloves
rasagiline
Azilect
Oral tablet
F
Single chemotherapy gloves
regorafenib
Stivarga
Oral tablet
NF
Single chemotherapy gloves
ribavirin
Rebetol; Ribasphere,
Moderiba
Oral capsule, oral tablet
F
Single chemotherapy gloves
ribavirin
Virazole
Solution for inhalation
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
riociguat
Adempas
Oral tablet
NF
Single chemotherapy gloves
romiDEPsin
Istodax
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
sevoflurane
Ultane
Solution for inhalation
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
sirolimus
Rapamune
Oral tablet
F
Single chemotherapy gloves
sirolimus
Rapamune
Oral solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
sonidegib
Odomzo
Oral capsule
NF
Single chemotherapy gloves
SORAfenib
Nexavar
Oral tablet
F
Single chemotherapy gloves
spironolactone
Aldactone
Oral tablet
F
Single chemotherapy gloves
spironolactone
CaroSpir
Oral suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
streptozocin
Zanosar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 18 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
SUNItinib
Sutent
Oral capsule
F
Single chemotherapy gloves
tacrolimus
Prograf
Oral capsule
F
Single chemotherapy gloves
tacrolimus
Prograf
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
tacrolimus
Protopic
Topical ointment
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
tamoxifen
N/A
Oral tablet
F
Single chemotherapy gloves
tamoxifen
Soltamox
Oral solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
temazepam
Restoril
Oral capsule
F
Single chemotherapy gloves
temozolomide
Temodar
Oral capsule
F
Single chemotherapy gloves
temozolomide
Temodar
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
temsirolimus
Torisel
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
teniposide
N/A
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
teriflunomide
Aubagio
Oral tablet
NF
Single chemotherapy gloves
testosterone
Striant
Buccal film
NF
Double chemotherapy gloves
Protective gown
testosterone
Aveed; Depo-Testosterone
Intramuscular injection
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
testosterone
Natesto
Nasal gel
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
Page 19 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
testosterone
AndroGel; AndroGel Pump;
Testim; Fortesta; Vogelxo
Topical gel
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
testosterone
Androderm
Transdermal patch
F
Double chemotherapy gloves
Protective gown
testosterone
Testopel
Subcutaneous implant
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
thalidomide
Thalomid
Oral capsule
F
Single chemotherapy gloves
thioguanine
Tabloid
Oral tablet
F
Single chemotherapy gloves
thiotepa
Tepadina
Solution for injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
tofacitinib
Xeljanz; Xeljanz XR
Oral tablet
F
Single chemotherapy gloves
topiramate
Qudexy XR; Topamax;
Topamax Sprinkle; Trokendi
XR
Oral tablet; oral capsule
F
Single chemotherapy gloves
topotecan
Hycamtin
Oral capsule
NF
Single chemotherapy gloves
topotecan
Hycamtin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
toremifene
Fareston
Oral tablet
NF
Single chemotherapy gloves
trabectedin
Yondelis
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
trametinib
Mekinist
Oral tablet
NF
Single chemotherapy gloves
trastuzumab
Herceptin
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
tretinoin
N/A
Oral capsule
F
Single chemotherapy gloves
tretinoin
Retin-A, Avita, Refissa,
Renova
Topical cream; topical gel
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
Respiratory protection if inhalation
possible
Page 20 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
triazolam
Halcion
Oral tablet
F
Single chemotherapy gloves
trifluridine + tipiracil
Lonsurf
Oral tablet
NF
Single chemotherapy gloves
triptorelin
Trelstar Mixject; Triptodur
Intramuscular suspension
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ulipristal acetate
Ella
Oral tablet
NF
Single chemotherapy gloves
urofollitropin
Bravelle
Solution for injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
valGANciclovir
Valcyte
Oral tablet
F
Single chemotherapy gloves
valGANciclovir
Valcyte
Oral solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
valproate sodium / valproic acid
Depakene; Depakote;
Depakote Sprinkles
Oral capsule, oral tablet
F
Single chemotherapy gloves
valproate sodium / valproic acid
Depakene
Oral solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
valproate sodium / valproic acid
Depacon
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
valrubicin
Valstar
Intravesical solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vandetanib
Caprelsa
Oral tablet
NF
Single chemotherapy gloves
vemurafenib
Zelboraf
Oral tablet
NF
Single chemotherapy gloves
venetoclax
Venclexta
Oral tablet
F
Single chemotherapy gloves
verteporfin
Visudyne
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vigabatrin
Sabril
Oral tablet
NF
Single chemotherapy gloves
Page 21 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
vigabatrin
Sabril; Vigadrone
Oral solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
vinBLAStine
N/A
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vinCRIStine
Vincasar PFS
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vinorelbine
Navelbine
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vismodegib
Erivedge
Oral capsule
NF
Single chemotherapy gloves
voriconazole
Vfend
Oral tablet
F
Single chemotherapy gloves
voriconazole
Vfend
Oral suspension
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
voriconazole
Vfend IV
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
vorinostat
Zolinza
Oral capsule
NF
Single chemotherapy gloves
warfarin
Coumadin; Jantoven
Oral tablet
F
Single chemotherapy gloves
zidovudine
Retrovir
Oral tablet; oral capsule
F
Single chemotherapy gloves
zidovudine
Retrovir
Oral syrup
F
Double chemotherapy gloves
Protective gown
Eye/face protection if there is potential
for patient vomiting or spitting up
zidovudine
Retrovir
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
ziprasidone
Geodon
Oral capsule
F
Single chemotherapy gloves
ziprasidone
Geodon
Intramuscular injection
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
Page 22 of 23
National Institutes of Health Clinical Center P&T Approved: March 28, 2019
HAZARDOUS DRUG LIST
Generic names
Brand names/Synonyms
Route and Dosage Forms
Formulary
Status
PPE For Administration
ziv-aflibercept
Zaltrap
Intravenous solution
NF
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
zoledronic acid
Reclast; Zometa
Intravenous solution
F
Double chemotherapy gloves
Protective gown
Eye/face protection if splash possible
CSTD required
zonisamide
Zonegran
Oral capsule
F
Single chemotherapy gloves
Page 23 of 23